Vt. lye victim gets new face at Boston hospital


BOSTON (AP) — A Vermont woman whose face was disfigured in a lye attack has received a face transplant.


Doctors at Boston's Brigham and Women's Hospital say 44-year-old Carmen Blandin Tarleton underwent the surgery earlier this month.


A team worked 15 hours to transplant the facial skin, including the neck, nose, lips, facial muscles, arteries and nerves.


The 44-year-old Tarleton, of Thetford, Vt., was attacked by her former husband in 2007. He doused her with industrial strength lye. She suffered chemical burns over 80 percent of her body. The mother of two wrote a book about her experience that describes her recovery.


It was the fifth face transplant at the Boston hospital.


Physicians are planning to discuss the case Wednesday at the hospital.


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Imperial County betting its future on renewable energy









Situated in the southeastern corner of California, bordering Arizona and Mexico, Imperial County has long depended on agriculture and cash crops that grew from the good earth.


But lately the region — which carries the dubious distinction of having the state's highest unemployment rate at 25.5% — is betting its future on a different kind of farm: green energy.


Spurred by a state mandate that requires utilities to get a third of their electricity from green sources by 2020, renewable energy companies are leasing or buying thousands of acres in Imperial County to convert to energy farms providing power for coastal cities — bringing an estimated 6,000 building jobs and billions in construction activity to the county.





Although renewable energy projects are sprouting up across the Golden State, no county needs them as much as Imperial, which has consistently ranked as the worst-performing region of California even in boom times.


The prospect of a construction boom has excited residents hungry for work. But some farmers and Native American tribes are crying foul, angry that the new projects are encroaching on land that they claim has cultural value or should be devoted to crops.


Solar, wind and geothermal projects are popping up on farms that once grew wheat, alfalfa and sugar beets. County officials say the normally hardscrabble region is benefiting from vast tracts of affordable land and lots of sunshine, the one resource the region can almost always count on.


"It's sunny 365 days of the year, damn near," boasted Mike Kelley, chairman of the county's Board of Supervisors. "Renewable energy is going to give Imperial County a shot in the arm."


Local advocates are betting that a "green rush" will lift a county that has struggled with economic upheaval. The Bureau of Labor Statistics just ranked El Centro as the second-worst metro area for job hunters, after Yuma, Ariz. Its unemployment rate fluctuated between 25% and 33% from 2010 and 2012.


Two of the county's top five employers are the Calipatria and Centinela state prisons. The agriculture sector shed jobs as farmers moved to automation and switched to less labor-intensive crops. Construction work vanished when El Centro, the county's biggest city, was hit hard by the housing crisis. Long-standing businesses such as a food processing plant moved elsewhere, taking away hundreds of jobs.


But with green energy companies scrambling to build solar installations and wind farms throughout the county, some residents are convinced that Imperial's fortunes will soon be looking up.


Tenaska Solar Ventures plans to break ground this year on its second project in the county after nearing completion on its first site, known as the Imperial Solar Energy Center South, on nearly 1,000 acres near El Centro.


The company came to the region both for its "abundant sunshine" and also proximity to the Sunrise Powerlink, a power transmission line completed last year that connects Imperial and San Diego counties, said Bob Ramaekers, Tenaska's vice president of development.


More than 500 construction workers have been hired to work on Tenaska Imperial South, with 70% coming from the local community, he said. A job fair held last year drew about 1,200 applicants. The second project will generate as many as 300 construction jobs, with priority given to local hires.


"One of the advantages of solar projects is they are not really high-tech. Anyone who has worked at all in the construction business can work in a solar facility," said Andy Horne, deputy executive officer of the county's natural resources department. "It's like a big erector set — you bolt these things together and ba-da-bing, you have a solar project."


The lure of a steady, well-paid job is what persuaded Victor Santana, 27, to start training as a journeyman electrician two years ago. He had studied film in college and hoped to make movies, but ended up working a series of odd jobs after the economic downturn — driving tractors, operating hay presses, selling vacuum cleaners. Even a video-editing gig he eventually found paid minimum wage,


"Things had dried up. There was only field work, or fast food, or working at the local mall," the El Centro resident said.


Santana finally decided to switch careers after hearing the pitch from green energy companies trickling into town. Now he earns about $21 an hour with regular raises every six months, and the prospect of steady work for another seven to 10 years just from the stream of solar and wind projects. "I feel a lot more secure than I did," he said.


Green energy may help Imperial hold onto its young people, who often try to land a government job or leave the county altogether in search of better-paying jobs elsewhere. Calipatria Unified School District is launching a vocational program this fall to prepare high school graduates for jobs in renewable energy. San Diego State is building a power plant simulator at its Brawley campus.


"With the advent of renewable energy, we are seeing a different kind of industrial base," said Mike Sabath, associate dean of academic affairs at San Diego State's Imperial Valley campus. "Hopefully that will provide opportunities to develop more job stability in the region than what we have enjoyed."


But construction has raised the hackles of some locals. There are farmers wringing their hands over fertile land snapped up by energy companies; they worry that a way of life is being edged out by corporations eager to cash in on the modern gold rush.





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The Lede: Comedian’s Blog Morphs Into Major Political Force in Italy

Last Updated, Tuesday, 10:08 a.m. Although an aide to the former prime minister Silvio Berlusconi demanded a recount late Monday, after his center-right coalition appeared to lose the battle for the Italian Parliament’s lower house to the main center-left coalition by less than 0.4 percent, a look at the raw vote totals reveals a sharp decline in support for him. According to the provisional count, Mr. Berlusconi’s party got about six million fewer votes than in 2008, slipping from first place all the way to third.

As my colleague Rachel Donadio explains, though, that did not spell a triumph for Mr. Berlusconi’s traditional rivals, the center-left Democratic Party, which lost nearly four million votes, because more than eight million Italians voted for the Five Star Movement, a party that emerged, fully formed, from the comedian Beppe Grillo’s popular blog. At the end of counting late Monday, Mr. Grillo’s party had more votes than any other in the lower house election and the second-most votes for Italy’s Senate.

While Mr. Grillo’s mass movement, which drew support from disenchanted voters on the left and the right, did not run as part of either main coalition and so will not lead Italy’s next government, the scale of the new party’s turnout, organized largely through the Internet and vast rallies, stunned observers.

In an update to nearly 1 million followers on Twitter, Mr. Grillo hailed the result, telling supporters, “We have become the leading force in absolute terms after just three and a bit years, without money, without ever having accepted the reimbursement of expenses.”

According to a translation on the English-language version of his blog, Mr. Grillo told supporters in a telephone interview streamed live on YouTube late Monday:

This adventure that we’re having is fantastic. First of all I just want to thank those extraordinary young people that made it possible to find the stages, the lights, the security services, the people that put us up in their homes, that have helped us with the camper. This is the difference between this grassroots movement and “the others”. “The others” are paid and are carried around in buses with flags. We are all volunteers. This is why so many thanks are needed.

Given that neither of the main coalitions will be able to command a majority, Mr. Grillo said, they will most likely have to combine to form an interim government until there can be fresh election. In the meantime, he added:

We are the obstacle. They can no longer succeed against us. Let them resign themselves to that. They’ll be able to keep going for 7 or 8 months and they’ll produce a disaster but we’ll try and keep them under control. We’ll start to do what we’ve always said – our stars: water in public hands, schools in public hands, public health service. If they follow us they follow us. If they don’t, the battle will be very harsh for them, very harsh.

Since the term of Italy’s president is also at an end, one of the first challenges facing Italy’s fractured new Parliament will be to elect a successor. In an update posted on Twitter on Tuesday, Mr. Grillo declared that his movement would decide who to support in an online ballot. Signalling change, he added, “Spring is coming.”

While the surge in support for Mr. Grillo’s party was described as a shock in many parts of the Italian and international media, there were clear signs of the Five Star Movement’s growing popularity in the series of late rallies Mr. Grillo called his #TsunamiTour on Twitter, culminating in a final campaign appearance attended by an estimated 800,000 in Rome’s Piazza San Giovanni.

Images of recent mass rallies for Beppe Grillo’s Five Star Movement.

One byproduct of Mr. Grillo’s success could be fresh elections, because the center-left coalition led by the Democratic Party, which spurned him as a potential candidate four years ago, is now unable to command a majority in the upper house and so may not be able to form a government. In a Twitter update on Tuesday, Mr. Grillo ruled out joining a governing coalition.

As the Guardian correspondent John Hooper noted, Mr. Grillo’s ability to tap into popular outrage over corruption in Italy, owes at least as much to his background in economics as to his comedian’s sharp tongue:

Grillo was born 64 years ago in Genoa and studied commercial economics. He might have ended up a provincial accountant.

His studies are the key to why he has such an acute perception of the many scandals in Italy in which politics and finance overlap, like the one enveloped its oldest bank, Monte dei Paschi di Siena, during the campaign. Grillo can read company accounts in a way few journalists and politicians can. The year before the Italian food giant, Parmalat, collapsed in 2003, Grillo forecast on television what was to be Europe’s biggest bankruptcy….

He disappeared from the state-owned RAI in 1993. Its rival network, Mediaset, had the odd satire programme, but none was allowed seriously to target the network’s proprietor, Silvio Berlusconi.

Grillo’s exclusion from television is crucial to understanding the man and his success. It added yet more anger to the ranting monologues that had become his speciality. And it forced him to turn to what was then a medium decidedly outside the mainstream, founding a blog that soon became a samizdat for the young, frustrated, indignant and internet-savvy.

As my colleagues Ian Fisher and Rob Harris explained in an article and a video report on Mr. Grillo in 2007, he first rallied popular support that year with his “V-Day,” based on the deep-seated desire of many Italians to dismiss their entire political class with an obscene phrase that starts with that letter in Italian.

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Jennifer Lawrence Dyes Her Hair Jet Black









02/26/2013 at 09:15 AM EST







Jennifer Lawrence, blonde (left) and brunette


Jason Merritt/Getty; AKM-GSI


Oscar's golden girl, Jennifer Lawrence, has gone brunette – almost jet black, in fact!

The day after winning Best Actress for her role in Silver Linings Playbook, Lawrence, 22, was right back at work – emerging from a Beverly Hills salon with newly dyed black hair as she prepares to play Katniss Everdeen in reshoots for the next Hunger Games movie.

The actress was dressed mostly in black, too – with a black cardigan and black skirt to go along with a gray T-shirt.

It was quite a contrast to her dazzling look on Sunday, with her golden hair and Dior Haute Couture dress with Chopard jewels, a Roger Vivier clutch and Brian Atwood shoes.

One thing she was still sporting, though, was her glowing smile.

Reshoots for The Hunger Games: Catching Fire are expected to begin as soon as this week, reportedly in Hawaii. The movie is due in theaters at Thanksgiving.

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Koop, who transformed surgeon general post, dies


With his striking beard and starched uniform, former Surgeon General Dr. C. Everett Koop became one of the most recognizable figures of the Reagan era — and one of the most unexpectedly enduring.


His nomination in 1981 met a wall of opposition from women's groups and liberal politicians, who complained President Ronald Reagan selected Koop, a pediatric surgeon and evangelical Christian from Philadelphia, only because of his conservative views, especially his staunch opposition to abortion.


Soon, though, he was a hero to AIDS activists, who chanted "Koop, Koop" at his appearances but booed other officials. And when he left his post in 1989, he left behind a landscape where AIDS was a top research and educational priority, smoking was considered a public health hazard, and access to abortion remained largely intact.


Koop, who turned his once-obscure post into a bully pulpit for seven years during the Reagan and George H.W. Bush administrations and who surprised both ends of the political spectrum by setting aside his conservative personal views on issues such as homosexuality and abortion to keep his focus sharply medical, died Monday at his home in Hanover, N.H. He was 96.


An assistant at Koop's Dartmouth College institute, Susan Wills, confirmed his death but didn't disclose its cause.


Dr. Richard Carmona, who served as surgeon general a decade ago under President George W. Bush, said Koop was a mentor to him and preached the importance of staying true to the science even if it made politicians uncomfortable.


"He set the bar high for all who followed in his footsteps," Carmona said.


Although the surgeon general has no real authority to set government policy, Koop described himself as "the health conscience of the country" and said modestly just before leaving his post that "my only influence was through moral suasion."


A former pipe smoker, Koop carried out a crusade to end smoking in the United States; his goal had been to do so by 2000. He said cigarettes were as addictive as heroin and cocaine. And he shocked his conservative supporters when he endorsed condoms and sex education to stop the spread of AIDS.


Chris Collins, a vice president of amFAR, the Foundation for AIDS Research, said many people don't realize what an important role Koop played in the beginning of the AIDS epidemic.


"At the time, he really changed the national conversation, and he showed real courage in pursuing the duties of his job," Collins said.


Even after leaving office, Koop continued to promote public health causes, from preventing childhood accidents to better training for doctors.


"I will use the written word, the spoken word and whatever I can in the electronic media to deliver health messages to this country as long as people will listen," he promised.


In 1996, he rapped Republican presidential hopeful Bob Dole for suggesting that tobacco was not invariably addictive, saying Dole's comments "either exposed his abysmal lack of knowledge of nicotine addiction or his blind support of the tobacco industry."


Although Koop eventually won wide respect with his blend of old-fashioned values, pragmatism and empathy, his nomination met staunch opposition.


Foes noted that Koop traveled the country in 1979 and 1980 giving speeches that predicted a progression "from liberalized abortion to infanticide to passive euthanasia to active euthanasia, indeed to the very beginnings of the political climate that led to Auschwitz, Dachau and Belsen."


But Koop, a devout Presbyterian, was confirmed after he told a Senate panel he would not use the surgeon general's post to promote his religious ideology. He kept his word.


In 1986, he issued a frank report on AIDS, urging the use of condoms for "safe sex" and advocating sex education as early as third grade.


He also maneuvered around uncooperative Reagan administration officials in 1988 to send an educational AIDS pamphlet to more than 100 million U.S. households, the largest public health mailing ever.


Koop personally opposed homosexuality and believed sex should be saved for marriage. But he insisted that Americans, especially young people, must not die because they were deprived of explicit information about how HIV was transmitted.


Koop further angered conservatives by refusing to issue a report requested by the Reagan White House, saying he could not find enough scientific evidence to determine whether abortion has harmful psychological effects on women.


Koop maintained his personal opposition to abortion, however. After he left office, he told medical students it violated their Hippocratic oath. In 2009, he wrote to Senate Majority Leader Harry Reid, urging that health care legislation include a provision to ensure doctors and medical students would not be forced to perform abortions. The letter briefly set off a security scare because it was hand delivered.


Koop served as chairman of the National Safe Kids Campaign and as an adviser to President Bill Clinton's health care reform plan.


At a congressional hearing in 2007, Koop spoke about political pressure on the surgeon general post. He said Reagan was pressed to fire him every day, but Reagan would not interfere.


Koop, worried that medicine had lost old-fashioned caring and personal relationships between doctors and patients, opened his institute at Dartmouth to teach medical students basic values and ethics. He also was a part-owner of a short-lived venture, drkoop.com, to provide consumer health care information via the Internet.


Koop was born in the New York City borough of Brooklyn, the only son of a Manhattan banker and the nephew of a doctor. He said by age 5 he knew he wanted to be a surgeon and at age 13 he practiced his skills on neighborhood cats.


He attended Dartmouth, where he received the nickname Chick, short for "chicken Koop." It stuck for life.


Koop received his medical degree at Cornell Medical College, choosing pediatric surgery because so few surgeons practiced it.


In 1938, he married Elizabeth Flanagan, the daughter of a Connecticut doctor. They had four children, one of whom died in a mountain climbing accident when he was 20.


Koop was appointed surgeon-in-chief at Children's Hospital in Philadelphia and served as a professor at the University of Pennsylvania School of Medicine.


He pioneered surgery on newborns and successfully separated three sets of conjoined twins. He won national acclaim by reconstructing the chest of a baby born with the heart outside the body.


Although raised as a Baptist, he was drawn to a Presbyterian church near the hospital, where he developed an abiding faith. He began praying at the bedside of his young patients — ignoring the snickers of some of his colleagues.


Koop's wife died in 2007, and he married Cora Hogue in 2010.


He was by far the best-known surgeon general and for decades afterward was still a recognized personality.


"I was walking down the street with him one time" about five years ago, recalled Dr. George Wohlreich, director of the College of Physicians of Philadelphia, a medical society with which Koop had longstanding ties. "People were yelling out, 'There goes Dr. Koop!' You'd have thought he was a rock star."


___


Ring reported from Montpelier, Vt. Cass reported from Washington. AP Medical Writers Lauran Neergaard in Washington and Mike Stobbe in New York contributed to this report.


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Does Eric Garcetti keep his word? Accounts vary









Santiago Perez and his neighbors went straight to Councilman Eric Garcetti when they heard that a developer planned to build a 62-unit housing and retail development on their quiet street in Echo Park.


Worried that the four-story complex would tower over homes and bring excess traffic, the group emerged from their meeting at Los Angeles City Hall feeling relieved. "He told us that, yes, he's with us and he will do everything possible to reject the plan," Perez said.


But months later in front of the citywide Planning Commission, a Garcetti representative offered the lawmaker's tacit support for the project, saying it was "designed well" and would bring needed jobs and housing to the area.





Perez and his neighbors felt blindsided. "He said one thing and then he did another," Perez said. One of his neighbors fired off an angry message via Twitter: "Eric Garcetti went back on his word."


If Garcetti succeeds in his bid to become L.A.'s next mayor, he will face new pressure to take decisive action on hotly contested issues. A number of colleagues and constituents say he has not always been a steadfast ally and decision maker.


Another mayoral front runner, Wendy Greuel, alluded to that allegation in a recent appearance before city workers, saying they need someone who will "be true to their word."


Garcetti insists he never wavers from a promise. In nearly 12 years in office, he has made decisions that have upset some people, he acknowledged. But the vast majority of people he has worked with have had positive experiences, he said.


He said that he never committed to fighting the Echo Park development and that he "reserves the right" to take his time forming a position on an issue. "I listen to a lot of people to make sure I'm as well-informed as possible up until the last hour," he said.


Councilman Bernard C. Parks, who has served alongside Garcetti for more than a decade, said Garcetti too often tests the political winds before taking a stand. Parks, who is backing Councilwoman Jan Perry's bid for mayor, alleges that Garcetti misled him last year by voting for a controversial redistricting plan after indicating he opposed it. Garcetti also undermined the city's efforts to hold down costs of employee union contracts, Parks said.


"I think he doesn't want to make an enemy of anyone," Parks said.


Garcetti said that he never told Parks he would oppose the redistricting plan and that the tough stance he took with the unions is "the reason I don't have [them] lining up behind me."


Questions of Garcetti's reliability arose for Marc Galucci, who went to the councilman for support in turning his Echo Park cafe into a restaurant serving beer and wine.


Galucci assembled neighbors to back his application for a liquor license for Fix Coffee, but parents of some children at a nearby school opposed it.


Galucci said Garcetti told him that he would remain neutral but offered suggestions on how to gain community support. Then, at 10 p.m. the night before the liquor license hearing, a Garcetti representative phoned. "Tomorrow at the hearing we're going to oppose this," she said.


"I was just flabbergasted," said Galucci. He later learned that Monica Garcia, president of the Board of the Los Angeles Unified School District, had asked Garcetti to oppose the request.


In the end, Galucci got the license, but he said the situation left him with a bad taste.


Garcetti acknowledged that the issue had been "a contentious one," but he said he had not pledged to remain neutral. He said that he initially liked the idea of a liquor permit for Fix but that community opposition "continued to grow and grow."


Former Councilwoman Jackie Goldberg, who has endorsed Garcetti, said that it's important to be flexible but that avoiding a strong stand can leave the wrong impression. "I do know that he is a person who tries to make people happy, and when you do that, people hear what they want to hear," she said.


On the campaign trail, Garcetti often touts his strengths as a consensus builder. Some current and former colleagues say his desire to find a compromise can be a weakness when consensus isn't possible.


Former City Councilman Greig Smith recalled a 2010 struggle in which the Department of Water and Power and Mayor Antonio Villaraigosa sought to raise rates to a level the council thought inappropriate. On the day of the vote, Garcetti and Perry appeared before the DWP commission to say the council would not support the plan.


When Garcetti returned to the council for a late-night hearing, he urged his colleagues to rethink the rate hike, according to Smith, who is supporting Perry. Smith said that before Garcetti had a chance to persuade his colleagues to reconsider the hike, Smith pushed through a vote to table it.


Garcetti disputes the account, saying he did not seek reconsideration.


In the wake of the DWP fight, Garcetti backed a successful ballot measure to create the Office of Public Accountability intended to scrutinize the utility. Jack Humphreville, an activist who has long complained about high salaries at the city-owned utility, said Garcetti's office at first seemed to support a multimillion-dollar budget for the office and broad powers for a ratepayer advocate.


Garcetti later allowed the ballot measure to be "neutered" after pressure from the utility workers union, Humphreville said. The ratepayer advocate's powers were reduced and its granted funding was cut.


"Eric agreed to all this stuff, and then he started backpedaling on us," Humphreville said.


Garcetti disagreed, saying the office has substantial powers.


Nick Patsaouras, a former DWP board member, said that he also was disappointed by the final measure but that Garcetti's concessions probably kept it from "being killed" entirely by labor advocates.


"I think Eric did well, considering," he said.


kate.linthicum@latimes.com





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IHT Rendezvous: Horsemeat Scandal Grows More Serious and More Bizarre

LONDON — As European governments struggle in vain to draw a line under the scandal over horsemeat being sold as beef, the affair seems only to be widening, in sometimes bizarre ways.

Two German politicians, for instance, suggested over the weekend that one practical use for tainted products, such as tens of thousands of packs of lasagna pulled from supermarket shelves because they contained horsemeat, would be to distribute them to the poor.

Page Two

Posts written by the IHT’s Page Two columnists.

The idea began with Hartwig Fischer, a lawmaker from Chancellor Angela Merkel’s Christian Democratic Union, who told the mass-circulation Bild Zeitung newspaper on Saturday that products shouldn’t just be thrown away. To prove his point, he was photographed and filmed eating one of the offending lasagna meals and declaring that he could not tell the difference from any other lasagna.

The development minister, Dirk Niebel, supported him, saying that, with hundreds of millions of starving people around the world, and people at home struggling to put food on the table, “I think we cannot throw away good food here in Germany.”

The idea did not meet with universal approval. The social affairs minister, Ursula von der Leyen, called it “absurd.” Some said transferring food without knowing the origin or nature of its ingredients could be illegal. And Andrea Nahles, general secretary of the opposition Social Democrats, called the very notion “an insult to people with low incomes.”

As I explore in my latest Letter From Europe column, the sensitivities about eating food packaged as beef but containing horsemeat are particularly acute in Britain.

But other nations are lining up to demand greater regulation of what goes into their processed food. On Monday, inspectors in the Czech Republic said they found horsemeat in the signature meatballs made in Sweden for the IKEA furniture group – not just food, but also a national emblem. The meatballs were distributed in the Czech Republic, Britain, Portugal, the Netherlands and Belgium, IKEA said, reflecting the gravity of the crisis and the likelihood that it will spread much further.

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Jennifer Lawrence: Her Most Memorable 2013 Awards Season Moments









02/25/2013 at 10:00 AM EST







Jennifer Lawrence at the Golden Globes (left), the SAG Awards and the Academy Awards


Jordan Strauss/Invision/AP; Kevin Winter/Getty


It wasn't just Jennifer Lawrence's wins making news during 2013's awards season.

The Silver Linings Playbook star, 22, was the subject of headlines for everything from her speeches to Sunday's tumble at the 85th Annual Academy Awards.

Relive Lawrence's most memorable moments here ...

Golden Globes

Lawrence kicked off awards season with an eyebrow-raising comment in her acceptance speech. After saying, "What does it say? I beat Meryl," some people – including Lindsay Lohan, who Tweeted about it – initially thought it was a jab at Meryl Streep. Lawrence later explained the comment to David Letterman, telling him it was a quote from The First Wives Club.

"First of all, it's Meryl Streep. You can't offend Meryl Streep," she said. "And then all of the sudden I hate Meryl Streep. Is that what this turned into? I don't like Meryl Streep? As if I had my eyes on getting that girl forever and I was like, 'Finally! I knew it would happen one day!' "

SAG Awards

Lawrence's Dior Haute Couture gown stole the show, but not just because of its beautiful style. While getting up to accept an award, the actress's "pants fell off," she later joked of what appeared to be a tear in the material. Lawrence, who showed off a lot of leg, made light of the incident on Piers Morgan.

Academy Awards

Hollywood's biggest night was memorable for Lawrence not only for walking away with the Best Actress statuette, but also for the way she received it. While getting up to accept the prestigious honor, she took a little tumble on the stairs in her Christian Dior Couture gown. After fellow nominee Hugh Jackman helped her up, she joked to the audience, "You guys are just standing up 'cause you feel bad that I fell and that's really embarrassing, but thank you."

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FDA approves new targeted breast cancer drug


WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.


The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.


Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.


"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."


Cobleigh helped conduct the key studies of the drug at the Chicago facility.


The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.


The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.


Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.


FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.


Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.


FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer


Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.


Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.


Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.


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Mahony answers questions under oath about clergy sex abuse cases









A "relatively unflappable" Cardinal Roger Mahony answered questions under oath for more than 3 1/2 hours Saturday about his handling of clergy sex abuse cases, according to the lawyer who questioned the former archbishop.


"He remained calm and seemingly collected at all times," said attorney Anthony De Marco, who represents a man suing the Los Angeles Archdiocese over abuse he alleges he suffered at the hands of a priest who visited his parish in 1987.


Mahony has been deposed many times in the past, but Saturday's session was the first time he had been asked about recently released internal church records that show he shielded abusers from law enforcement.





De Marco declined to detail the questions he asked or the answers the cardinal provided, citing a judge's protective order.


The deposition occurred just before Mahony was to board a plane for Italy to vote in the conclave that will elect the next pope. In a Twitter post Friday, Mahony wrote that it was "just a few short hours before my departure for Rome."


Church officials did not return requests for comment.


The case, set for trial in April, concerns a Mexican priest, Nicholas Aguilar Rivera. Authorities believe he molested at least 26 children during a nine-month stay in Los Angeles.


Recently released church files show Aguilar Rivera fled to Mexico after a top Mahony aide, Thomas Curry, warned him that parents were likely to go the police and that he was in "a good deal of danger." Aguilar Rivera remains a fugitive in Mexico.


The archdiocese had agreed that Mahony could be questioned for four hours about the Aguilar Rivera case and 25 other priests accused in the same period. De Marco said he did not get to ask everything he wanted and would seek additional time after the cardinal returned from the Vatican.


Past depositions of Mahony have eventually become public, and De Marco said he would follow court procedures to seek the release of a transcript of Saturday's deposition.


Meanwhile, a Catholic organization Saturday delivered a petition with thousands of signatures asking that Mahony recuse himself from the conclave in Rome.


The group, Catholics United, collected nearly 10,000 signatures making "a simple request" that the former archbishop of Los Angeles not participate in the process because of the priest abuse scandals that happened under his watch, said Chris Pumpelly, communications director for Catholics United.


The petition was delivered Saturday to St. Charles Borromeo in North Hollywood, where the cardinal resides. It was accepted by a church staff member.


After delivering the petition, organizers attended Mass at the parish to pray for healing and for the future of the church.


harriet.ryan@latimes.com


Times staff writer Rick Rojas contributed to this report.





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